Exploring Polynucleotides

The Fountain of Youth in a Syringe?


Since the days of Ponce de León, humankind has been captivated by the mythical Fountain of Youth and the pursuit of flawless, ageless skin. In modern times, we have made great strides with skincare technology and anti-aging treatments. The latest innovation – polynucleotide injections – taps into our own DNA to refresh skin from the inside out.

What are these magical Polynucleotides?

Polynucleotides are natural amino acid sequences that make part of DNA.

Polynucleotides are derived from fish sperm cells! The nucleic acids that form DNA are extracted from salmon and trout and purified into chains of rejuvenating goodness and combined with hyaluronic acid to improve its effectiveness in the injectable product.

When expertly injected into the skin, they send signals that spark youthful collagen production and cell turnover for nourished, glowing skin.

A “Facelift in a Syringe”

Clinical studies have shown polynucleotides can improve skin texture, elasticity, and radiance while erasing fine lines, wrinkles, dark spots and redness. As one of our regenerative dermatologists put it, they provide a “facelift in a syringe!” The catch? Results take time as your body builds new collagen over 90 days after the initial cellular wakeup call. But once injected, polynucleotides keep working for months with no need for top up treatments. 

Brand Names: Crystal PDRN, Rejuran, Ameela, Lumi Eyes


Effects of the Polynucleotides

  • Exhibit anti-inflammatory properties
  • Trophic effect on human fibroblasts in primary culture and stimulate the secretion activity of collagen proteins and other proteins of the extracellular matrix (ECM).
  • Hydrating effect by attracting moisture, restoring the ECM, and improving elasticity and tone.
  • Enhance vascular endothelial growth factor (VEGF) within skin tissue, which strengthens microcirculation and promotes deoxyribonucleic acid (DNA) synthesis, enhancing remodelling of skin tissue.
  • Strengthen the skin barrier and have anti-inflammatory effects, improving erythema
  • Accelerate the repair of damaged DNA caused by ultraviolet B (UVB) or reactive oxygen species (ROS) through the de novo salvage pathway.

Could polynucleotides banish aging for good? Only time will tell, but the future looks bright for these innovative treatments.

What do Polynucleotides do?

Polynucleotides injected in the skin, signal to the skin cells and promote DNA repair, which in turn promote wound healing, reduce excessive inflammation, prevent excessive scar tissue formation and repair healthy ECM.

Anti-inflammatory effects are achieved via boosted cell renewal, collagen and elastin stimulation and improves dermal medium to promote optimal environment for hyaluronic acid. In short, Polynucleotides are not dermal fillers i.e. a gel material which gives volume until removed or dissolved. PN solution once placed in the skin gives regenerative instructions to skin cells and stimulate healthy skin regeneration. They are as close to natural treatments as it goes. to improved skin texture, reduce discoloration and small increases in volume and tightness – especially under the eyes and neck area.

PN have proven stimulatory effects, which are helpful in anthropic scar treatment, post-surgical scars, preventing hair loss and growth stimulation.

Where can you use polynucleotides?

PN activate specialised undifferentiated cells which can differentiate to dermal cells, myofibroblasts and adipocytes, hence they can be used anywhere in the body and skin.

Injectable treatments are aimed at:

  • skin health restoration
  • underlying ligaments health, especially in periorbital area i.e. weakened ligaments cause the puffiness and bags
  • hair loss
  • atrophic scars
  • barrier restoration
  • inflammatory skin conditions such as rosacea and dermatitis

How long does it take to see results?

PNs differ from most common injectables because the results take time. They are injected similarly as skin boosters and dermal fillers but don’t give immediate effect.

Initially PN may cause light swelling for 3-5 days, before being completely absorbed into the skin. However, true desired effect may take around 90 days to emerge as skin has to change its behaviour at a cellular level.


A few remarks:

PN can not cause any lumps, mumps, or overfilling. Multiple treatments are required for best results as the treatment effect depends on skin condition, age and underlying damage of the DNA.

How often can you use polynucleotides?

Recommendation is to have 1 session per month for 4-6 consecutive months to build up the ultimate effect (a process called ‘loading regimen’). After this, maintenance varies from person to person – though using it monthly will have no harmful effect and will continue to improve skin over time.

The Future is Now

While polynucleotides show great promise as next-gen anti-aging treatments, more research and trials are underway to fully reveal their rejuvenating superpowers. But based on current findings, it’s clear that PN injections can safely improve various visible signs of aging and poor skin health. They tap into our cells’ own repair processes to refresh our complexions over time through natural collagen regeneration.

The possibilities seem endless when we unlock the secrets of our DNA. So instead of pursuing mythical fountains, look to the future where science-based solutions arise. Seek out one of Aestha Clinic’s highly qualified practitioners to learn if polynucleotide treatments may be right for your skin and anti-aging goals. Schedule a consultation today to determine if these DNA-enhancing injections can turn back time for your unique complexion needs. Let our experts guide you, as together we ride this thrilling wave into skincare’s next revolutionary chapter.

Book your appointment today!