Your Skin's Natural Path to Collagen Revival
JULAINE vs Other Popular Biostimulators
At Aestha Clinic, we’re thrilled to introduce JULAINE, the revolutionary next generation biostimulator that’s transforming how we approach skin regeneration. Unlike traditional volumising treatments, JULAINE represents true biohacking of your skin’s ability to reverse ageing by working at the cellular level to enhance your body’s natural collagen, elastin, and fibronectin production.
What makes JULAINE special? It’s not just another filler – it’s bioregenerative treatment designed for stemcell and fibroblast stimulation that enhances your skin’s natural ability to produce the essential proteins that keep skin youthful, firm, and healthy.
Understanding JULÄINE: The Science of Advanced PLLA Technology
JULÄINE is a PLLA-based medical device designed to help preserve your own natural youthfulness through superior collagen regeneration produced with high purity biomaterials. The patented science reflects over 15 years of research focused on developing the purest technology of biomaterials.
Key Benefits of JULÄINE:
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- True skin regeneration – not volumising treatment
- Enhanced natural collagen production targeting collagen, elastin, and fibronectin
- Subtle volume improvement through enhanced skin health
- Reduction in dynamic skin level lines
- Long-lasting structural support for up to 2 years
JULÄINE’s unique PLLA-based formula offers deeper, longer-lasting collagen stimulation with uniform-size, high purity PLLA microspheres that produce only healthy Type1 collagen, eliminating risks of inflammation, fibrosis, or nodules.

How JULAINE Differs from Other PLLA Biostimulators
JULAINE vs Sculptra, Lenisna, and Juvelook
While these treatments are all PLLA-based, JULAINE sets itself apart through its advanced molecular design:
Revolutionary Differences:
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- No inflammation induction – Unlike traditional PLLA products that work through inflammatory responses, JULAINE’s advanced design targets low-level skin inflammation
- Zero granuloma risk – Does not form scar tissue, eliminating the lumps and fibrosis associated with other PLLA-based products
- Superior purity – JULAINE consists of uniform-size, high purity PLLA microspheres with homogeneous and smooth surfaces, allowing for good tissue integration with inflammation or potential for granuloma minimised
Clinical Advantage: While other PLLA treatments like Sculptra trigger inflammatory biological reactions, JULAINE offers a more controlled approach with its advanced microsphere technology that degrades slowly and predictably
JULÄINE vs PROFHILO
Targeting Different Aspects of Skin Health
PROFHILO: The Hydration Powerhouse Profhilo is composed of pure hyaluronic acid with unique ability to attract and retain water molecules up to 1000 times its weight, making it highly effective in hydrating the skin from within for a fresh and radiant appearance
JULÄINE: The Structural Regenerator While Profhilo excels at:
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- Rapid skin glow and hydration
- Bio-remodelling through HA
- Immediate plumping effects lasting 6 months
JULÄINE targets:
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- Collagen, fibronectin and elastin production by enhancing skin fibroblast activity
- Redensification and improved skin quality for long-lasting effects
- Structural support and long-term collagen stimulation up to 2 years
Profhilo provides immediate hydration and plumping, while JULÄINE works on deeper tissue repair for improvement in both skin quality and firmness
JULÄINE vs Polynucleotides
Different Approaches to Skin Regeneration
Polynucleotides: The DNA Repair System Polynucleotides are chains of nucleotides derived from salmon DNA that stimulate skin regeneration and collagen production, working as structural ingredients for DNA and skin amino acids stimulation
Key Differences:
Aspect |
Polynucleotides
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Julaine Biostimulator
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Primary action
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DNA structural building blocks for amino acid stimulation
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Biodegradable polymer mimicking biological molecules
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Results
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Rapid skin glow, hydration, precursors for anti-ageing
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Redensification, long-term collagen bio-stimulation
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Mechanism
|
Attracts water molecules, boosts fibroblasts, reduces inflammation, repairs
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Promotes tissue repair through advanced fibroblast stimulation
|
Duration
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Up to 12 months
|
Up to 24 months |
Focus
|
Cellular repair and hydration | Structural support and collagen stimulation |
The Perfect Combination: These treatments complement each other beautifully – polynucleotides provide rapid skin glow and hydration, while JULÄINE offers structural support and long-term collagen stimulation.

Ideal Candidates for Julaine Bioregenerative Treatment
JULÄINE is recommended for patients seeking:
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- Natural regenerative skin solutions
- Enhanced skin health and quality
- Prevention and bio-remodeling (from 25 years old)
- Improved collagen and elastin levels in sun-damaged skin
- Non-volumising treatment with subtle volume improvement
Specific Indications:
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- Ageing signs – fine lines, loss of elasticity
- Skin health improvement – texture, firmness, density
- Sun damage recovery – enhanced collagen and elastin production
- Immune-compromised patients – suitable due to excellent safety profile
- Full body treatment – can be used on face and body areas
The Science Behind Superior Results
JULÄINE’s time-controlled degradation of microspheres ensures a constant source of product in the tissue, achieving a gradual increase in type III and type I collagen for long-lasting results
Clinical Advantages:
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- Biocompatible microspheres allow excellent tissue integration
- Controlled degradation provides predictable biological effects
- High density microspheres with optimal shape and size
- Progressive PLLA release for active regenerative effects
Safety Profile: Why JULÄINE Leads the Way
JULÄINE is CE-marked for safety and has undergone rigorous clinical testing, with practitioners reporting high safety profiles and comfortable, easy injection experiences
Safety Benefits:
- No risk of granulomas or fibrosis
- Suitable for immune-compromised patients
- Minimal side effects
- No inflammation induction
- Excellent tissue tolerance
The information provided is for educational purposes. Individual results may vary. Please consult with our qualified practitioners at Aestha Clinic for personalised treatment recommendations.
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At our clinic, we understand that achieving natural-looking rejuvenation requires both advanced techniques and personalised treatment plans.
We take pride in offering this cutting-edge treatment as part of our commitment to providing effective, minimally invasive solutions that work with your body’s natural processes rather than against them.