At Aestha Clinic, we believe that maintaining facial aesthetics during GLP-1-assisted weight loss requires a multi-dimensional approach. Our treatment philosophy is built on three core principles:

• • Prevention Before Correction: Intervening early yields superior, more natural results
  • Multi-Layered Treatment: Addressing all facial tissue layers for comprehensive support
  • Personalised Protocols: Tailoring treatments to your unique facial anatomy, age, and weight loss goals

Before recommending any treatments, we conduct a thorough facial analysis to understand your unique needs:

Our Advanced Assessment Process

• • 3D Facial Mapping: Precise documentation of your facial structure and volume distribution
  • Skin Quality Analysis: Measuring hydration, elasticity, thickness, and collagen density
  • Dynamic Movement Assessment: Evaluating how facial expressions affect your appearance
  • Weight Loss Projection: Understanding your weight loss goals and timeline

This detailed assessment allows us to create a truly personalised treatment plan that evolves with your changing face throughout your weight loss journey.

At Aestha Clinic, we understand that effective facial preservation during GLP-1 weight loss requires a customised, multi-modal approach. Rather than offering rigid, one-size-fits-all solutions, we combine various treatments into an integrated protocol uniquely tailored to your specific needs. Our treatment toolkit includes three core categories that are typically mixed and combined for optimal results:

1. Collagen Biostimulators

The foundation of facial preservation is rebuilding and maintaining your skin’s collagen matrix. We select from several advanced biostimulators based on your specific needs:

• • Sculptra: The first proven regenerative biostimulator with a unique poly-L-lactic acid (PLLA-SCA™) formulation, clinically validated in GLP-1 patients
  • Lenisna: A next-generation biostimulator with enhanced volumising properties
  • Juvelook: Particularly effective for early intervention in younger patients
  • Lanluma: Providing both immediate and long-term collagen stimulation
  • Radiesse: Offering immediate structural support while stimulating collagen

2. Startegic Volume Restoriation

While biostimulators address skin quality and provide gradual volumisation, strategic filler placement offers immediate structural support to crucial facial areas:

• • Restylane Lyft™ or Contour™: Clinically proven in GLP-1 patients to provide effective midface support
  • Custom Filler Selection: Choosing from our comprehensive range based on your specific needs
  • Precision Placement: Targeted application in the midface, temples, jawline, and key structural support points

3. Advanced Skin Tightening Technologies

To address skin laxity and enhance overall skin quality, our energy-based treatments complete the comprehensive approach:

• • Fotona 4D Lift: Four-dimensional laser treatment targeting multiple tissue layers
  • Ultrasound (USS): Focused ultrasound energy to tighten deep tissue planes
  • Nano CO2 Laser: Fractional skin resurfacing for texture and tone improvement
  • RF Microneedling: Combining radiofrequency energy with microneedling for enhanced collagen stimulation

What makes Aestha Clinic’s approach unique is our understanding that these treatments work synergistically and also our extensive range of top-tier medical devices and products.

How We Combine Treatments:

1. Layered Tissue Targeting: Each facial tissue layer receives appropriate treatment:

• • • Deep planes: Biostimulators and ultrasound technologies
    • Mid-level: Strategic filler placement and RF technologies
    • Superficial: Laser treatments and skincare

2. Synchronised Timing: Treatments are strategically scheduled to enhance each other:

• • • Energy-based treatments may precede injectables to prepare the tissue
    • Biostimulators and fillers often administered in the same session
    • Treatment intervals strategically timed to your weight loss progression

3. Progressive Enhancement: Your treatment plan evolves as your weight loss progresses:

• • • Initial focus may be preventative biostimulation with minimal fillers
    • Mid-journey adjustments might include more targeted volume replacement
    • Later stages often incorporate more intensive skin tightening

Clinical Evidence Supporting Combined Approaches:

The 2025 Galderma study specifically utilised a combined protocol where patients received:

• • Sculptra and either Restylane Lyft™ or Contour™ for their first treatment
  • A second Sculptra treatment with optional Restylane touch-up at Week 4
  • An optional third Sculptra treatment at Week 8

This integrated approach delivered impressive results:

• • Significant improvements in facial contour and skin quality
  • 85% of patients reporting a more refreshed appearance by Week 4
  • 89% feeling more attractive with natural-looking results at three months

At Aestha Clinic, we create truly customised treatment plans that mix and match from our toolkit based on your unique needs. While each plan is individualised, here are some common combination approaches we find effective:

For Patients Just Starting GLP-1 Medications

Primary Focus: Prevention and Preservation Common Treatment Combination:

• • Foundation: Sculptra or Juvelook treatment to stimulate collagen production before significant volume loss
  • Integration: Often combined in the same session with minimal strategic filler in key support areas
  • Enhancement: Typically followed by Fotona 4D Lift 2-3 weeks later to optimise tissue response
  • Progression: Subsequent treatments mix additional biostimulators with targeted energy treatments based on your weight loss pace and facial changes

This preventative approach allows us to stay ahead of facial changes, rather than chasing them after they appear. Many patients find this combined protocol minimises the need for more extensive treatments later.

For Patients Midway Through Their Weight Loss Journey

Primary Focus: Maintenance and Support Common Treatment Combination:

• • Foundation: More intensive combination of Sculptra with Lenisna for comprehensive biostimulation
  • Integration: Typically paired with strategic Restylane placement in areas already showing volume loss
  • Enhancement: Often alternating between RF Microneedling and biostimulator sessions for synergistic effects
  • Progression: As weight loss continues, the balance between biostimulation and direct volume replacement shifts based on your individual response

At this stage, combining immediate volume replacement with ongoing collagen stimulation provides both short-term improvement and long-term support as weight loss continues.

For Patients After Significant Weight Loss

Primary Focus: Restoration and Refinement Common Treatment Combination:

• • Foundation: Comprehensive protocol mixing multiple biostimulators (often Sculptra with Lanluma or Radiesse) for maximum collagen response
  • Integration: Combined with more extensive filler treatments in multiple facial areas during the same sessions
  • Enhancement: Intensive combination of Ultrasound and RF Microneedling, often with overlapping treatment areas for maximum tissue response
  • Progression: Many patients benefit from alternating between combined injectable sessions and energy-based treatments at 3-4 week intervals

This multi-modal approach addresses the more significant changes that have already occurred while building a foundation for ongoing improvement. The specific combination of treatments evolves as your facial tissues respond and improve.

Your age significantly impacts both how GLP-1 medications affect your face and which treatment mixtures will work best for you. Our practitioners create customised combinations based on your unique facial anatomy and aging pattern:

For Patients in Their 30s

Typical Concerns: Subtle volume loss, early skin quality changes Effective Treatment Combinations:

• • Early Stage Mix: Juvelook combined with Fotona 4D Lift, often in alternating sessions 2-3 weeks apart
  • Targeted Approach: Lighter Sculptra treatments mixed with minimal strategic filler only in specific areas showing early volume loss
  • Preventative Combination: For some patients, alternating between RF Microneedling and strategic biostimulator placement provides ideal preventative results

Even in younger patients, we find that combined approaches yield superior results to single-modality treatments, particularly in maintaining skin quality during rapid weight changes.

For Patients in Their 40s

Typical Concerns: More noticeable volume loss, visible skin laxity Effective Treatment Combinations:

• • Comprehensive Approach: Full Sculptra protocol often combined with Restylane in the same session, followed by RF Microneedling 2-3 weeks later
  • Layered Strategy: Many patients benefit from a mix of technologies targeting different tissue depths – biostimulators for deep planes, fillers for mid-level volume, and energy treatments for surface quality
  • Customised Rotation: Typically alternating between injectable sessions (combining biostimulators and fillers) and energy-based treatments for ongoing improvement

At this age, the synergistic effects of combined treatments become even more important as both collagen loss and volume depletion accelerate during GLP-1 weight loss.

For Patients in Their 50s and Beyond

Typical Concerns: Significant volume loss, pronounced skin laxity Effective Treatment Combinations:

• • Intensive Foundation: Typically beginning with a combination session of Sculptra and Lenisna for maximum collagen stimulation, plus targeted Restylane placement for immediate structure
  • Multi-Technology Approach: Often mixing Ultrasound technology with RF Microneedling in the same treatment session for comprehensive tissue tightening
  • Strategic Layering: Many patients benefit from a planned sequence of treatments – often beginning with deeper tissue treatments and progressing to more superficial approaches as initial results develop

For mature patients, our experience shows that the most successful outcomes come from thoughtfully combining multiple treatment modalities in a strategic sequence, with each treatment enhancing and building upon the others.

Our protocols are directly informed by the latest clinical research, including the groundbreaking 2025 Galderma study that specifically examined facial volume loss in patients using GLP-1 medications.

This phase IV clinical trial demonstrated that the combination of Sculptra (biostimulator) and Restylane products (hyaluronic acid fillers) delivered impressive results:

• • Significant improvements in “mid-face shape and contouring”
  • Enhanced skin quality, including “significantly improving skin radiance and thickness”
  • Improved skin hydration maintained through follow-up visits
  • High patient satisfaction, with 89% feeling “more attractive and happier with their appearance”

The safety profile was excellent, with no treatment-related adverse events reported, confirming that these protocols are both effective and well-tolerated.

When you choose Aestha Clinic for your facial preservation during GLP-1 weight loss, we create a dynamic treatment journey that evolves with your changing needs:

1. Initial Consultation and Comprehensive Assessment

• • 3D facial analysis and documentation
  • Discussion of your weight loss goals and timeline
  • Educational review of potential facial changes
  • Exploration of treatment options from our full toolkit

2. Dynamic Treatment Planning

• • Development of your integrated treatment protocol
  • Creation of a flexible treatment map that evolves with your journey
  • Strategic mixing of treatments for optimal synergistic effects
  • Clear explanation of how different treatments complement each other

3. Ongoing Monitoring and Protocol Refinement

• • Regular reassessment during active weight loss phases
  • Real-time adjustment of treatment combinations based on your response
  • Continuous optimisation of the balance between biostimulation, volume replacement, and skin tightening
  • Adjustment of treatment intervals and intensity as needed

4. Long-Term Integrated Maintenance Strategy

• • Transition to a maintenance combination as weight stabilises
  • Development of an optimised treatment mix for long-term results
  • Strategic scheduling of complementary treatments
  • Ongoing adjustment based on your aging pattern and lifestyle

The beauty of our approach is its flexibility and personalisation. Rather than strict protocols, we create a dynamic treatment journey that continuously adapts to your changing face, combining different elements of our treatment toolkit in the most effective way for your unique situation.

At Aestha Clinic, we understand that the most effective solutions for GLP-1-related facial changes come not from single treatments used in isolation, but from thoughtfully combined approaches that address multiple tissue layers simultaneously.

The groundbreaking Galderma clinical research confirms what we’ve observed in our practice: the combination of biostimulators with fillers produces superior results to either treatment alone. Our experience further shows that integrating energy-based treatments creates an even more comprehensive solution.

By mixing and matching from our treatment toolkit—selecting the right biostimulators, fillers, and energy-based technologies for your unique situation—we create a truly personalised approach that evolves with your changing face throughout your weight loss journey.

You shouldn’t have to choose between achieving your weight management goals and maintaining your facial aesthetics. With our integrated treatment approach, you can successfully navigate GLP-1-assisted weight loss while preserving—and even enhancing—your facial appearance.

We invite you to schedule your GLP-1 Facial Preservation consultation at Aestha Clinic today. Let our expert team create your customised treatment combination to maintain your confidence and appearance throughout your transformation.

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