At the heart of skin health lies the extracellular matrix—a complex network composed of collagen, elastin, proteoglycans, and glycosaminoglycans. This matrix provides not just structural support but also regulates crucial cellular functions. With age, sun damage, and persistent inflammation, this vital framework deteriorates. Collagen becomes fragmented and disorganised, elastin diminishes, and hydration decreases—resulting in skin that appears thin, lacklustre, and increasingly lined.

At Aestha Clinic, we’ve pioneered a powerful combination approach to comprehensively rebuild and rejuvenate this matrix: VI Peel combined with polynucleotides and PRP therapy, targeting both visible sun damage and underlying inflammatory processes.

VI Peel: Cellular Renewal and Matrix Stimulation

The VI Peel represents a significant advancement in chemical peel technology, specifically formulated to address photodamage while stimulating matrix renewal. This effective sun damage treatment thoroughly exfoliates damaged surface cells, removing accumulated evidence of sun exposure while penetrating deeper to trigger collagen synthesis in the dermis, initiating repair of the extracellular matrix. The VI Peel effectively breaks down irregular pigmentation while simultaneously stimulating cellular renewal, creating a more even tone and texture. Most importantly, it prepares the skin for maximum absorption and effectiveness of the advanced treatments that follow. The VI Peel effectively addresses skin elastosis—the degradation of elastic fibers that results from sun damage—by stimulating the production of new elastin fibers. This restoration of elasticity is crucial for regaining the skin’s youthful resilience and firmness, creating an ideal foundation for comprehensive rejuvenation.

Polynucleotides for Skin Repair

Polynucleotides are sophisticated DNA-derived compounds that function as biological regulators in the skin. These remarkable molecules provide essential building blocks for DNA repair in cells damaged by sun exposure and effectively scavenge free radicals, neutralising oxidative stress. Polynucleotides directly interact with cell receptors to down-regulate inflammatory pathways and enhance hydration within the dermal matrix by binding water molecules, making them ideal for treating sun-damaged skin.

PRP (Platelet Rich Plasma)

PRP, derived from your own blood plasma, contains concentrated platelets that release powerful growth factors upon activation. These growth factors stimulate fibroblast proliferation, increasing collagen production, enhance microcirculation to deliver vital nutrients, activate dormant stem cells in the tissue, and orchestrate the complex processes of tissue repair and matrix remodelling.

When combined with VI Peel, these advanced treatments create transformative synergistic benefits:

• Enhanced Regeneration and Collagen Production:
  Both promote collagen synthesis through complementary mechanisms—PRP delivers growth factors that directly trigger production, while polynucleotides enhance fibroblast activity. Together, they significantly boost both collagen and elastin formation, resulting in firmer, more youthful skin texture after sun damage.
• Optimised Skin Hydration and Matrix Structure:
  Polynucleotides excel at retaining moisture and protecting against matrix degradation, while PRP nourishes with essential proteins. This combination comprehensively restores structural integrity and improves the matrix’s water-binding capacity for lasting hydration.
• Advanced Healing and Inflammation Control:
  PRP releases growth factors that orchestrate repair, while polynucleotides reduce inflammatory cytokines. This dual-action approach effectively resets the skin’s inflammatory environment, breaking the cycle of inflammaging and allowing true regeneration to occur.
• Targeted Cellular Matrix Repair:
  Together they create an optimal environment for matrix remodelling and regeneration, addressing sun damage, skin aging, scarring, and pigmentation issues at their source rather than merely masking symptoms.
• Comprehensive Rejuvenation:
  The VI Peel with polynucleotides and PRP combination improves texture, reduces fine lines, and restores natural luminosity by targeting both visible signs and underlying cellular processes of ageing.
• Enhanced Treatment Response:
  This powerful trio primes the skin for better outcomes from other aesthetic procedures, with reduced recovery time and improved results.

First Session: Initiating Skin Matrix Regeneration

• • Thorough skin assessment to document specific sun damage concerns and establish a baseline
  • Careful application of VI Peel, customised to your skin’s condition and sun damage needs
  • Strategic administration of polynucleotides with PRP through micro-injections
  • Breaking the cycle of inflammation and beginning the process of matrix repair
  • Noticeable improvement in skin texture and tone following the initial 5-7 day healing period

Second Session: Enhancing Skin Matrix Structure

• • Scheduled 2-4 weeks after first VI Peel treatment to build upon the established foundation
  • Evaluation of skin response and refinement of the protocol based on individual results
  • Second VI Peel application to further address sun damage pigmentation while continuing collagen stimulation
  • Polynucleotides with PRP focused specifically on enhancing matrix quality and organisation
  • Strengthening of initial results with improved firmness, elasticity and further inflammation reduction

Third Session: Optimising Results

• • Conducted 2-4 weeks after second treatment for optimal progression
  • Final VI Peel adjusted to refine texture and address any remaining sun damage pigmentation concerns
  • Polynucleotides with PRP application to lock in improvements by stabilising the regenerated matrix
  • Completion of the regenerative cycle and establishment of new baseline skin health
  • Ensuring benefits are not only visible but sustainable for long-term results

This comprehensive approach delivers significant improvements that continue to develop over time. Patients typically experience 50-70% reduction in hyperpigmentation from sun damage, visibly enhanced structural integrity, and increased firmness and elasticity within weeks of the first VI Peel treatment.

What makes this protocol particularly effective is its ability to create lasting change by addressing the root causes of skin aging and sun damage. By neutralising inflammation and supporting comprehensive matrix regeneration, the treatment doesn’t just improve appearance temporarily—it changes how your skin will age going forward.

This powerful combination therapy with VI Peel, polynucleotides and PRP is particularly effective for individuals experiencing:

• visible sun damage,
• loss of skin firmness,
• signs of premature aging,
• dull skin unresponsive to topical treatments,
• post-inflammatory hyperpigmentation.

The VI Peel treatment is suitable for most skin types and can be customised to address your specific sun damage concerns.

Experience the transformative power of this revolutionary combination and rediscover skin that looks not just younger, but genuinely healthier. Contact Aestha Clinic today to schedule your consultation for VI Peel with polynucleotides and PRP therapy.

Restore. Repair. Revitalise. Your journey to healthier skin and reduced sun damage begins at Aestha Clinic.

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