Your Skin's Natural Path to Collagen Revival

JULAINE vs Other Popular Biostimulators

At Aestha Clinic, we’re thrilled to introduce JULAINE, the revolutionary next generation biostimulator that’s transforming how we approach skin regeneration. Unlike traditional volumising treatments, JULAINE represents true biohacking of your skin’s ability to reverse ageing by working at the cellular level to enhance your body’s natural collagen, elastin, and fibronectin production.

What makes JULAINE special? It’s not just another filler – it’s bioregenerative treatment designed for stemcell and fibroblast stimulation that enhances your skin’s natural ability to produce the essential proteins that keep skin youthful, firm, and healthy.

Understanding JULÄINE: The Science of Advanced PLLA Technology

JULÄINE is a PLLA-based medical device designed to help preserve your own natural youthfulness through superior collagen regeneration produced with high purity biomaterials. The patented science reflects over 15 years of research focused on developing the purest technology of biomaterials.

Key Benefits of JULÄINE:

    • True skin regeneration – not volumising treatment
    • Enhanced natural collagen production targeting collagen, elastin, and fibronectin
    • Subtle volume improvement through enhanced skin health
    • Reduction in dynamic skin level lines
    • Long-lasting structural support for up to 2 years

JULÄINE’s unique PLLA-based formula offers deeper, longer-lasting collagen stimulation with uniform-size, high purity PLLA microspheres that produce only healthy Type1 collagen, eliminating risks of inflammation, fibrosis, or nodules.

lasynpro technology

How JULAINE Differs from Other PLLA Biostimulators

JULAINE vs Sculptra, Lenisna, and Juvelook

While these treatments are all PLLA-based, JULAINE sets itself apart through its advanced molecular design:

Revolutionary Differences:

    • No inflammation induction – Unlike traditional PLLA products that work through inflammatory responses, JULAINE’s advanced design targets low-level skin inflammation
    • Zero granuloma risk – Does not form scar tissue, eliminating the lumps and fibrosis associated with other PLLA-based products
    • Superior purity – JULAINE consists of uniform-size, high purity PLLA microspheres with homogeneous and smooth surfaces, allowing for good tissue integration with inflammation or potential for granuloma minimised

Clinical Advantage: While other PLLA treatments like Sculptra trigger inflammatory biological reactions, JULAINE offers a more controlled approach with its advanced microsphere technology that degrades slowly and predictably

JULÄINE vs PROFHILO

Targeting Different Aspects of Skin Health

PROFHILO: The Hydration Powerhouse Profhilo is composed of pure hyaluronic acid with unique ability to attract and retain water molecules up to 1000 times its weight, making it highly effective in hydrating the skin from within for a fresh and radiant appearance

JULÄINE: The Structural Regenerator While Profhilo excels at:

    • Rapid skin glow and hydration
    • Bio-remodelling through HA
    • Immediate plumping effects lasting 6 months

JULÄINE targets:

    • Collagen, fibronectin and elastin production by enhancing skin fibroblast activity
    • Redensification and improved skin quality for long-lasting effects
    • Structural support and long-term collagen stimulation up to 2 years

Profhilo provides immediate hydration and plumping, while JULÄINE works on deeper tissue repair for improvement in both skin quality and firmness

JULÄINE vs Polynucleotides

Different Approaches to Skin Regeneration

Polynucleotides: The DNA Repair System Polynucleotides are chains of nucleotides derived from salmon DNA that stimulate skin regeneration and collagen production, working as structural ingredients for DNA and skin amino acids stimulation

Key Differences:

Aspect
Polynucleotides 
Julaine Biostimulator
Primary action
DNA structural building blocks for amino acid stimulation
Biodegradable polymer mimicking biological molecules
Results
Rapid skin glow, hydration, precursors for anti-ageing
Redensification, long-term collagen bio-stimulation
Mechanism
Attracts water molecules, boosts fibroblasts, reduces inflammation, repairs
Promotes tissue repair through advanced fibroblast stimulation
Duration
Up to 12 months
Up to 24 months
Focus
Cellular repair and hydration Structural support and collagen stimulation

 

The Perfect Combination: These treatments complement each other beautifully – polynucleotides provide rapid skin glow and hydration, while JULÄINE offers structural support and long-term collagen stimulation.

julaine vs sculptra, polynucleotides and profhilo

Ideal Candidates for Julaine Bioregenerative Treatment

JULÄINE is recommended for patients seeking:

    • Natural regenerative skin solutions
    • Enhanced skin health and quality
    • Prevention and bio-remodeling (from 25 years old)
    • Improved collagen and elastin levels in sun-damaged skin
    • Non-volumising treatment with subtle volume improvement

Specific Indications:

    • Ageing signs – fine lines, loss of elasticity
    • Skin health improvement – texture, firmness, density
    • Sun damage recovery – enhanced collagen and elastin production
    • Immune-compromised patients – suitable due to excellent safety profile
    • Full body treatment – can be used on face and body areas

The Science Behind Superior Results

JULÄINE’s time-controlled degradation of microspheres ensures a constant source of product in the tissue, achieving a gradual increase in type III and type I collagen for long-lasting results

Clinical Advantages:

    • Biocompatible microspheres allow excellent tissue integration
    • Controlled degradation provides predictable biological effects
    • High density microspheres with optimal shape and size
    • Progressive PLLA release for active regenerative effects

Safety Profile: Why JULÄINE Leads the Way

JULÄINE is CE-marked for safety and has undergone rigorous clinical testing, with practitioners reporting high safety profiles and comfortable, easy injection experiences

Safety Benefits:

  • No risk of granulomas or fibrosis
  • Suitable for immune-compromised patients
  • Minimal side effects
  • No inflammation induction
  • Excellent tissue tolerance

The information provided is for educational purposes. Individual results may vary. Please consult with our qualified practitioners at Aestha Clinic for personalised treatment recommendations.

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At our clinic, we understand that achieving natural-looking rejuvenation requires both advanced techniques and personalised treatment plans. 

We take pride in offering this cutting-edge treatment as part of our commitment to providing effective, minimally invasive solutions that work with your body’s natural processes rather than against them.